货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T96319-1ml	10mM in DMSO	￥720.00 T96319-1ml ￥720.00 现货	6 6	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T96319-1ml

10mM in DMSO

￥720.00

产品描述：

AMPK 活化剂;AMPK Activators;;InformationASP4132 ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0.018 μM. ASP4132 is used as a clinical candidate for the treatment of human cancer.TargetsAMPK (Cell-free assay) 0.018 μM(EC50)In vitroASP4132 is a new type of AMPK activator with potent AMPK activation activity and attractive selective growth inhibition against human cancer cells, improves aqueous solubility, metabolic stability and animal pharmacokinetics (PK). Studies on ASP4132 have advanced to clinical trials for the treatment of cancer.In vivoThe in vivo efficacy of ASP4132 is evaluated via MDA-MB-453 xenografts in nude mice. The tumor growth inhibition (TGI) rate is 29% at 1 mg/kg (p.o.), and the tumor regression rate is 26%, 87% and 96% at 2, 4 and 8 mg/kg, respectively. All doses of ASP4132 are well tolerated over the 21-day dosing window, and no body weight loss is observed.Cell Research(from reference)Cell lines：MDA-MB-453, SK-BR-3, AU565, OCUB-M, Concentrations：0.3 nM, 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 300 nM, 1000 nM, 3000 Nm Incubation Time：2 h, 4 days

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.067 ml	5.336 ml	10.672 ml
5 mM	0.213 ml	1.067 ml	2.134 ml
10 mM	0.107 ml	0.534 ml	1.067 ml
50 mM	0.021 ml	0.107 ml	0.213 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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