P450(例如CYP17)抑制剂;P450(e.g. CYP17) Inhibitors;;InformationNVP-VID-400 NVP-VID-400 (SDZ285428) is an inhibitor of CYP51 . NVP-VID-400 (SDZ285428) inhibits T. cruzi and T. brucei with I/E 2 a (5 min) of both <1 and I/E 2 (60 min) of 9 and 35, respectively.TargetsCYP51
体内研究:
Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases.