货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T96541-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T96541-1ml ￥648.00 现货	3 3	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T96541-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

HDAC6 选择性抑制剂;HDAC6 Selective Inhibitors;;InformationSKLB-23bb is an orally bioavailableHDAC6-selectiveinhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.TargetsHDAC6 (Cell-based assay) <100 nMIn vitroSKLB-23bb shows cytotoxic effects against a panel of solid and hematologic tumor cell lines at the low submicromolar level. In contrast to the reported HDAC6-selective inhibitors, SKLB-23bb is more efficient against solid tumor cells. SKLB-23bb selectively inhibits cellular HDAC6, but the antitumor activity of SKLB-23bb is independent of HDAC6. SKLB-23bb could bind to the colchicine site in β-tubulin and act as a microtubule polymerization inhibitor. It blocks tumor cell cycle at G2-M phase and triggers cellular apoptosis.In vivoIn solid tumor xenografts, oral administration of SKLB-23bb efficiently inhibits tumor growth. SKLB-23bb has good pharmacokinetic profiles and is orally bioavailable.Cell Research(from reference)Cell lines：HCT116 and A2780S cells Concentrations：200 nM Incubation Time：3, 6, 12 and 24 h

靶点：

IC50: 17 nM (HDAC6), 422 nM (HDAC1), 398 nM (HDAC8)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.522 ml	12.612 ml	25.224 ml
5 mM	0.504 ml	2.522 ml	5.045 ml
10 mM	0.252 ml	1.261 ml	2.522 ml
50 mM	0.05 ml	0.252 ml	0.504 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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