Abeprazan 以剂量依赖性方式抑制胃酸分泌,在使用幽门结扎大鼠、管腔灌注大鼠模型的各种体内研究中,Abeprazan 对胃酸分泌的抑制作用等于或大于先前批准的 P-CAB 伏诺拉赞和 heidenhain pouch dog 模型。
参考文献:
1. Sunwoo J, et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2018 Jul;48(2):206-218.