| 靶点: |
Kd:33 nM (R15B-PP1c holophosphatase) |
| 体内研究: |
Raphin1 improves weight of HD82Q mice treated from 4 to ∼10 weeks of age with 2 mg/kg of Raphin1 once a day by oral gavage. Raphin1 also decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in the cortex of HD82Q mice. |
| 参考文献: |
1. Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
4.328 ml |
21.638 ml |
43.275 ml |
| 5 mM |
0.866 ml |
4.328 ml |
8.655 ml |
| 10 mM |
0.433 ml |
2.164 ml |
4.328 ml |
| 50 mM |
0.087 ml |
0.433 ml |
0.866 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |