脱氢酶抑制剂;Dehydrogenase Inhibitors;;InformationML390 ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.TargetsDHODH (Cell-free assay) 0.56 μMIn vitroML390 was active with an ED50 (effective concentration triggering 50% of its maximal differentiation activity) of 2 μM in murine and human AML cell lines, offering insight into the mechanism of overcoming differentiation arrest. DHODH inhibitors demonstrated effective at prolonging survival in animal models of leukemia.Cell Research(from reference)Cell lines:Lys-GFP-ER-HoxA9 cells Concentrations:10 μM Incubation Time:48 h