| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T96868-1ml促销 |
10mM in DMSO | ￥720.00 ￥648.00 |
6 | - | - | - | - |
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| 产品描述： | 表观遗传阅读器域抑制剂;Epigenetic Reader Domain Inhibitors;;InformationPF-CBP1 HCl PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP) .It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.TargetsCREBBP (Cell-free assay); p300/CBP (Cell-free assay) 125nM; 363nMIn vitroPF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson\'s disease.It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high.Cell Research(from reference)Cell lines：mouse J774 macrophage-like cell line Concentrations：0.1-10\xa0μM Incubation Time：30min | ||||||||||||||||||||
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| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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