| 产品描述： | ATM 选择性抑制剂 | 活化剂;ATM Selective Inhibitors | Activators;;InformationAZ31 is a selective and novelATMinhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ).TargetsATMIn vitroAntitumor effects of AZ31 + SN38 are cytostatic rather than cytotoxic.In vivoPharmacokinetic investigation of AZ31 as a single agent and in combination with irinotecan revealed that plasma concentrations of AZ31 were highest 1-hour after administration followed by a stepwise decrease at 3, 6 and 16 hour in the combination sensitive CRC098.Cell Research(from reference)Cell lines：CRC (metastatic colorectal cancer) HCT15, HCT116, RKO, CaCo2, LS123 and LOVO Concentrations：1.25, 2.5 or 5 μmol/L Incubation Time：72 hours |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京