含溴结构域蛋白4抑制剂;Contains brominated domain protein 4 inhibitors;;InformationFL-411 FL-411 (BRD4-IN-1) is a potent and selective inhibitor of Bromodomain-containing protein 4 (BRD4) with IC50 of 0.43 μM for BRD4(1). FL-411 induces ATG5-dependent autophagy -associated cell death (ACD) by blocking BRD4-AMPK interaction.TargetsBRD4(1) (Cell-free assay) 0.43 μM