| 产品描述： | HDAC8 选择性抑制剂;HDAC8 Selective Inhibitors;产品介绍：TH34是HDAC抑制剂，对HDAC6、HDAC8和HDAC10的选择性比HDAC1、HDAC2和HDAC3高。在 NanoBRET实验中，TH34与HDAC6/8/10紧密结合，IC50分别为4.6 μM、1.9 μM和7.7 μM。;InformationTH34 is aHDACinhibitor that shows pronounced selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3. In a NanoBRET assay, TH34 strongly binds HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM).TargetsHDAC8 ; HDAC6 ; HDAC10 1.9 μM; 4.6 μM; 7.7 μMIn vitroTH34 strongly binds to HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM), and shows no substantial affinity to HDAC2 at concentrations up to 50 µM. Its treatment induces hyperacetylation of tubulin and SMC3. TH34 effectively and selectively eliminates high-grade neuroblastoma cells while sparing non-transformed human cells. In neuroblastoma cell lines as well as primary neuroblastoma cells, it markedly induces DNA damage, followed by differentiation and G2/M phase cell cycle arrest at later timepoints, eventually leading to cell death.Cell Research(from reference)Cell lines：SK-N-BE(2)-C cells Concentrations：10 μM Incubation Time：48 h |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京