| 产品描述： | 表观遗传阅读器域抑制剂;Epigenetic Reader Domain Inhibitors;;InformationZL0420 ZL0420 is a potent and selective BRD4 inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 respectively and good selectivity over that of the related BRD2 homolog.TargetsBRD4 BD1 (Cell-free assay); BRD4 BD2 (Cell-free assay) 27 nM; 32 nMIn vitroZL0420 has a relatively high clearance and low exposures with oral bioavailability not favorable in vivo. Intravenous administration of ZL0420 gives an excellent drug exposure (high AUC value) and moderate half-life. |
| 参考文献： |
1. Zhiqing Liu, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.375 ml |
16.874 ml |
33.747 ml |
| 5 mM |
0.675 ml |
3.375 ml |
6.749 ml |
| 10 mM |
0.337 ml |
1.687 ml |
3.375 ml |
| 50 mM |
0.067 ml |
0.337 ml |
0.675 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
