货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T97173-1ml促销	10mM in DMSO	￥720.00 ￥570.00 T97173-1ml ￥570.00 现货	4 4	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T97173-1ml促销

10mM in DMSO

￥720.00 ￥570.00

产品描述：

DNA-PK 抑制剂;DNA-PK Inhibitors;;InformationAZD7648 AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases.TargetsDNA-PK (Cell-free assay) 0.6 nMIn vitroAZD7648 inhibits IR-induced DNA-PK S2056 auto phosphoryalation with an IC50 = 92 nM in A549 non-small cell lung cancer (NSCLC) cells. In A549 cells, AZD7648 (≥1 µM) in combination with 2Gy IR for 48 hours leads to a significant accumulation of cells arrested in the G2/M of the cell cycle, a 4-fold increase in micronuclei formation, and 3-fold induction of γH2AX, pATM S1981 and 53BP1 foci formation compared with IR alone.In vivoAZD7648 is a potent and highly selective DNA-PK inhibitor, with good crystalline solubility, permeability and metabolic stability, good bioavailability and predictable pharmacokinetics in preclinical species, and potent knockdown of pRPA and regressions in murine xenograft models when combining with olaparib or radiation.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.629 ml	13.144 ml	26.288 ml
5 mM	0.526 ml	2.629 ml	5.258 ml
10 mM	0.263 ml	1.314 ml	2.629 ml
50 mM	0.053 ml	0.263 ml	0.526 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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