| 产品描述: | 产品介绍:FH1 (NSC 12407) 可增强肝细胞功能,并促进诱导多能干 (iPS) 衍生的肝细胞向更成熟的表型分化以及分化良好的肝细胞样细胞 (iHeps) 培养物的成熟。;InformationFH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.In vitroFH1(BRD-K4477) enhances hepatocyte functions, and promotes the maturation of well-differentiated cultures of iHeps, which potentially alleviates a major obstacle to the use of iPS cells as a renewable source of functional human hepatocytes. |
| 参考文献: |
1. Schepers AG, et al. Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function. ACS Chem Biol. 2021 Sep 17;16(9):1770-1778. 2. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9(8):514-20. 3. Lunzhi Yuan, et al. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection. Front Microbiol. 2018 May 8;9:908. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
3.542 ml |
17.709 ml |
35.418 ml |
| 5 mM |
0.708 ml |
3.542 ml |
7.084 ml |
| 10 mM |
0.354 ml |
1.771 ml |
3.542 ml |
| 50 mM |
0.071 ml |
0.354 ml |
0.708 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |