| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T97680-1ml促销 |
10mM in DMSO | ￥4680.00 ￥4210.00 |
货期：3-5天 | - | - | - | - |
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| 产品描述： | 非选择性组蛋白赖氨酸甲基转移酶抑制剂;Non-selective histone lysine methyltransferase inhibitor;Chaetocin, a natural product originally produced by Chaetomium species, is shown to have apoptotic effects on some cancer cells. Mechanistic studies show that chaetocin is taken up in the cells by a process that requires intact/unreduced disulfides for uptake. Once inside, this compound imposes oxidative stress and consequent apoptosis induction. Other studies have shown chaetocin to reduce lysine-specific histone methyltransferase effects of SUV39H, which play a key role in maintaining stable gene expression patterns during embryonic development and cellular differentiation. Additionally, this agent is reported to cause profound chromatin reorganization in fibroblast nuclei by inducing chromatin condensation/clustering. Consequentially, chaetocin impairs Trx (thioredoxin) systems, which are essential for deoxynucleotide synthesis and involved in a broad range of cellular functions. Chaetocin is an inhibitor of G9a, SUV39H1 and TrxR1.;Chaetocin, a natural product originally produced by Chaetomium species, is shown to have apoptotic effects on some cancer cells. Mechanistic studies show that chaetocin is taken up in the cells by a process that requires intact/unreduced disulfides for uptake. Once inside, this compound imposes oxidative stress and consequent apoptosis induction. Other studies have shown chaetocin to reduce lysine-specific histone methyltransferase effects of SUV39H, which play a key role in maintaining stable gene expression patterns during embryonic development and cellular differentiation. Additionally, this agent is reported to cause profound chromatin reorganization in fibroblast nuclei by inducing chromatin condensation/clustering. Consequentially, chaetocin impairs Trx (thioredoxin) systems, which are essential for deoxynucleotide synthesis and involved in a broad range of cellular functions. Chaetocin is an inhibitor of G9a, SUV39H1 and TrxR1. | ||||||||||||||||||||
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| 靶点： | IC50: 0.6 μM (HMT), 4 μM (TrxR) | ||||||||||||||||||||
| 体内研究： | 在存在或不存在抑制剂的情况下培养 SL-2 果蝇组织细胞。Chaetocin 对培养的细胞有毒性作用。当将 Chaetocin 添加到培养物中时，毒性高度依赖于初始细胞密度。当细胞在含有 0.5 μM Chaetocin 的培养基中生长 5 天后，在 Lys9 (H3K9me2) 处二甲基化的 H3 分子数量显著减少。从用 0.1 μM 处理更短时间的细胞中分离的组蛋白也显示 Lys9 甲基化下降，但不如用更高浓度时那么强烈。 | ||||||||||||||||||||
| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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