| 产品描述： | 缺口抑制剂;Notch Inhibitors;;InformationIMR-1A IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.TargetsNotch (Cell-free assay); Notch (Cell-free assay) 0.5 μM; 2.9 μM(Kd) |
| 靶点： |
IC50: 0.5 μM (Notch) |
| 体内研究： |
IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.074 ml |
15.368 ml |
30.735 ml |
| 5 mM |
0.615 ml |
3.074 ml |
6.147 ml |
| 10 mM |
0.307 ml |
1.537 ml |
3.074 ml |
| 50 mM |
0.061 ml |
0.307 ml |
0.615 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京