货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T98292-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T98292-1ml ￥648.00 现货	6 6	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T98292-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

Rho抑制剂;Rho Inhibitors;;InformationY16 Y16 is an inhibitor of G-protein-coupled Rho GEFs . It blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM).TargetsRhoGEFsIn vitroY16 binds to the junction site of the DH-PH domains of LARG with a ∼80 nM Kd and suppresses LARG catalyzed RhoA activation dose dependently. It is active in blocking the interaction of LARG and related G-protein–coupled Rho GEFs with RhoA without a detectable effect on other DBL family Rho GEFs, Rho effectors, or a RhoGAP. In cells, Y16 selectively inhibits serum-induced RhoA activity and RhoA-mediated signaling, effects that can be rescued by a constitutively active RhoA or ROCK mutant. By suppressing RhoA activity, Y16 inhibits mammary sphere formation of MCF7 breast cancer cells but does not affect the nontransforming MCF10A cells. Y16 works synergistically with Rhosin/G04, a Rho GTPase activation site inhibitor, in inhibiting LARG–RhoA interaction, RhoA activation, and RhoA-mediated signaling functions. Y16 effectively inhibits the growth, migration, and invasion activities of breast cancer cells.Cell Research(from reference)Cell lines：PC-3 cells Concentrations：10 μM Incubation Time：36 h

靶点：

Kd: 76 nM (LARG)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.601 ml	13.006 ml	26.013 ml
5 mM	0.52 ml	2.601 ml	5.203 ml
10 mM	0.26 ml	1.301 ml	2.601 ml
50 mM	0.052 ml	0.26 ml	0.52 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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