促进人间充质干细胞向软骨细胞的分化;Promotes differentiation of human mesenchymal stems cells into chondrocytes;Kartogenin是一种smad4/smad5通路激活剂,促进多功能间充质干细胞选择性分化为软骨细胞。;Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.An inducing factor of mesenchymal stem cells into chondrocytes
体内研究:
Kartogenin(10 μM,溶于 4μL 盐水中;在第 7 天和第 21 天处理)可促进胶原酶 VII 诱导的小鼠 OA 模型中的软骨修复。