COX抑制剂;COX Inhibitors;;Informationα-Cyperone α-Cyperone (alpha-cyperone), a major active compound of Cyperus rotundus, exhibits biological activities, such as antivirulence, antigenotoxic, and antibacterial activities. α-Cyperone (alpha-cyperone) is associated with the down-regulation of COX-2 , IL-6 , Nck-2 , Cdc42 and Rac1 .
体内研究:
在 LPS 刺激的 RAW 264.7 细胞中,alpha-Cyperone 的抗炎活性通过负调节 NFκB 通路与 COX-2 和 IL-6 的下调有关。 alpha-Cyperone 与微管蛋白结合并相互作用,能够明显破坏微管聚合的稳定性。这种相互作用的作用可能导致炎症减少,这对处理炎症性疾病如 AD 非常有益。