| 产品描述: | 水溶性一氧化碳释放分子;Water-soluble carbon monoxide-releasing molecule;CORM-3(一氧化碳(CO)释放分子-3)已可用于研究其对巨噬细胞糖酵解所致NLRP3(含热蛋白结构域3富含亮氨酸重复序列的受体)炎性体激活以及高血糖症诱导的 IL-1β(白细胞介素-1 β)产生的影响。它还被用于研究其对原代兔晶状体上皮细胞中 H2O2诱导的细胞凋亡的保护作用; |
| 体内研究: |
CORM-3 (4 mg/kg, ip) reduces NLRP3 inflammasome activation and inhibits hyperglycemia-induced inflammation in mice. |
| 参考文献: |
1. Foresti R, et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142(3):453-60. 2. Lee DW, et al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493(2):957-963. 3. Huang Y, et al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)-induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
3.394 ml |
16.972 ml |
33.943 ml |
| 5 mM |
0.679 ml |
3.394 ml |
6.789 ml |
| 10 mM |
0.339 ml |
1.697 ml |
3.394 ml |
| 50 mM |
0.068 ml |
0.339 ml |
0.679 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |