| 产品描述: | Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素, 有潜力用于阿狄森氏病的研究,可减少尿液中钠丢失量, 也用于增加血压。 |
| 体内研究: |
Fludrocortisone acetate (250 μg/kg/天,口服) 与 1% 盐水 (NaCl) 溶液结合可引起大鼠心脏损伤,降低抗氧化酶 (GSH、SOD 和 CAT) 活性。 Fludrocortisone acetate (0.05 mg/kg,口服,每日两次,连续 4 天) 可导致健康猫的 UACR 显著下降。 |
| 参考文献: |
1. Fitzgerald M, et al. Mineralocorticoids restore quiescent morphology and reduce VEGF receptor expression in inflamed choroidal endothelial cells in vitro. Ophthalmic Res. 2009;41(1):44-52. 2. Sarker M, et al. Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway. Biomed Pharmacother. 2024 Dec;181:117703. 3. Djajadiningrat-Laanen SC, et al. Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate. J Vet Intern Med. 2008 Nov-Dec;22(6):1283-8. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.367 ml |
11.835 ml |
23.669 ml |
| 5 mM |
0.473 ml |
2.367 ml |
4.734 ml |
| 10 mM |
0.237 ml |
1.183 ml |
2.367 ml |
| 50 mM |
0.047 ml |
0.237 ml |
0.473 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |