| 产品描述： | E1 激活抑制剂;E1 Activating Inhibitors;;InformationDKM 2-93 DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5) .TargetsUBA5In vitroDKM 2-93 not only impairs pancreatic cancer cell survival in PaCa2, but also Panc1 cells with 50 % effective concentration values of 90 and 30 μM, respectively.In vivoDKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.Cell Research(from reference)Cell lines：PaCa2 and Panc1 pancreatic cancer cells Incubation Time：48 h |
| 靶点： |
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells) |
| 体内研究： |
在免疫缺陷小鼠的肿瘤异种移植研究中，DKM 2-93 每日处理显著抑制 PaCa2 细胞体内的肿瘤生长，而不会导致任何体重减轻或明显毒性。 |
| 参考文献： |
1. Roberts AM, et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target. ACS Chem Biol. 2017 Apr 21;12(4):899-904. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
4.104 ml |
20.518 ml |
41.036 ml |
| 5 mM |
0.821 ml |
4.104 ml |
8.207 ml |
| 10 mM |
0.41 ml |
2.052 ml |
4.104 ml |
| 50 mM |
0.082 ml |
0.41 ml |
0.821 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京