| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T99708-1ml促销 |
10mM in DMSO | ￥190.00 ￥170.00 |
9 | - | - | - | - |
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| 产品描述： | 肌内质网Ca 2+ -ATPase（SERCA）抑制剂;Sarco-endoplasmic reticulum Ca 2+ -ATPase (SERCA) inhibitor;2,5-二叔丁基对苯二酚是用于测量铜（II）酶样催化剂催化活性的氧化底物。2，5-二叔丁基对苯二酚(DBHQ)已被证明是SERCA(内质网Ca2+-ATPase)的一种选择性和有效的抑制剂，该抑制剂被证明能诱导激动剂不敏感和激动剂敏感的细胞内储存物释放Ca2+。在分离的大鼠肝细胞研究中，据报道DBHQ诱导细胞溶质Ca2+浓度快速增加，而不损失其他微粒体酶活性，改变膜渗透性或微粒体蛋白硫醇的修饰。;2,5-Di-tert-butylhydroquinone is the oxidation substrate used to measure the catalytic activity of the copper(II) enzyme-like catalysts.2,5-Di-tert-butylhydroquinone (DBHQ) has been shown to be a selective and potent inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which is shown to cause induction of Ca2+ release from agonist-insensitive and agonist-sensitive intracellular stores. In isolated rat hepatocyte studies, DBHQ was reported to induce a rapid increase in cytosolic Ca2+ concentration without loss of other microsomal enzyme activity, altering membrane permeability, or modification of microsomal protein thiols. | ||||||||||||||||||||
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| 参考文献： | 1. Kempton RJ, et al. Heck- and Suzuki-coupling approaches to novel hydroquinone inhibitors of calcium ATPase. Beilstein J Org Chem. 2019 Apr 24;15:971-975. 2. Zsofia Kutil, et al. The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Food and Agricultural Immunology. Volume 26, 2015-Issue 4. |
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| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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