Adenosine 5'-Triphosphate, disodium salt is a p2 purinergic (P2X and P2Y) agonist that increases Ca2+-activated K+ channel activity. It has been found to induce a release of prostoglandin D2 and histamine from rat peritoneal mast cells in a dose-dependent manner.
体内研究:
ATP disodium salt(50 mg/kg;腹腔注射)可保护小鼠免受体内细菌感染。 ATP disodium salt 可诱导 IL1β、KC 和 MIP-2 的分泌以及中性粒细胞的体内募集。