| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V36607-1mg |
≥98% | ￥828.00 |
货期：3-5天 | - | - | - | - |
|
V36607-5mg |
≥98% | ￥2000.00 |
货期：3-5天 | - | - | - | - |
|
V36607-10mg |
≥98% | ￥2800.00 |
货期：3-5天 | - | - | - | - |
|
V36607-25mg |
≥98% | ￥4130.00 |
货期：3-5天 | - | - | - | - |
|
V36607-50mg |
≥98% | ￥5610.00 |
货期：3-5天 | - | - | - | - |
|
V36607-100mg |
≥98% | ￥7430.00 |
货期：3-5天 | - | - | - | - |
|
V36607-200mg |
≥98% | ￥9830.00 |
货期：3-5天 | - | - | - | - |
|
| 体内研究： | 5HT6-ligand-1 is extensively metabolized in rat liver microsomes whereas in human liver microsomes, 5HT6-ligand-1 is extensively metabolized (90%). The IC50 values for 5HT6-ligand-1 at CYP 3A4 is 35.97%, whereas the IC50 values at CYP 2D6 enzymes is less than 20 μM. 5HT6-ligand-1 at an oral dose of 10 mg/kg is rapidly absorbed in rats with a good oral half-life of 3.17±0.49 h with an oral bioavailability of 29±5%. The observed oral Cmax is 60±44 ng/mL and occurs at 1.83 h. 5HT6-ligand-1 displays an oral exposure of 217±92 ng h/mL. It has a clearance of 220±92 mL/min/kg with a volume of distribution of 32.6±10.7 L/kg for iv dose. Extensive rat metabolism coupled with high clearance could be the possible reason for moderate oral bioavailability showed by 5HT6-ligand-1. Oral administration of 5HT6-ligand-1 reverses the time delay induced memory deficit and statistically significant effect is observed at a dose of 10 mg/kg indicating cognitive improvement potential of the compound 6a. | ||||||||||||||||||||
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| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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