| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V36767-1mg |
≥99% | ￥1980.00 |
货期：3-5天 | - | - | - | - |
|
V36767-5mg |
≥99% | ￥4920.00 |
货期：3-5天 | - | - | - | - |
|
V36767-10mg |
≥99% | ￥7130.00 |
货期：3-5天 | - | - | - | - |
|
V36767-25mg |
≥99% | ￥10600.00 |
货期：3-5天 | - | - | - | - |
|
V36767-50mg |
≥99% | ￥14200.00 |
货期：3-5天 | - | - | - | - |
|
| 靶点： | IC50: 39 nM (trypsin), 950 nM (plasmin) and 1.9 μM (thrombin) | ||||||||||||||||||||
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| 体内研究： | Patamostat mesylate (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner. Patamostat mesylate (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis. Patamostat mesylate (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats. |
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| 参考文献： | 1. K Miyamoto, et al. [Effects of E-3123, a New Protease Inhibitor, on Several Protease Activities and on Experimental Acute Pancreatitis]. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93. 2. T Hirano, et al. Protective Effect of a Cephalosporin, Shiomarin, Plus a New Potent Protease Inhibitor, E3123, on Rat Taurocholate-Induced Pancreatitis. J Gastroenterol Hepatol. Jan-Feb 1993;8(1):52-9. |
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| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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