| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V37278-1mg |
≥99% | ￥430.00 |
货期：3-5天 | - | - | - | - |
|
V37278-5mg |
≥99% | ￥740.00 |
货期：3-5天 | - | - | - | - |
|
V37278-10mg |
≥99% | ￥1240.00 |
货期：3-5天 | - | - | - | - |
|
V37278-25mg |
≥99% | ￥2470.00 |
货期：3-5天 | - | - | - | - |
|
V37278-50mg |
≥99% | ￥4230.00 |
货期：3-5天 | - | - | - | - |
|
V37278-100mg |
≥99% | ￥5880.00 |
货期：3-5天 | - | - | - | - |
|
V37278-200mg |
≥99% | ￥8250.00 |
货期：3-5天 | - | - | - | - |
|
| 靶点： | Nox1 Nox2 Nox4 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究： | APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line. In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes. |
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| 体内研究： | APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice. APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. |
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| 溶解性： | DMSO : 100 mg/mL (316.66 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 备注： | 1. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. 2. Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431. |
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| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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