| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V37279-1mg |
≥99% | ￥1290.00 |
货期：3-5天 | - | - | - | - |
|
V37279-5mg |
≥99% | ￥3290.00 |
货期：3-5天 | - | - | - | - |
|
V37279-10mg |
≥99% | ￥4730.00 |
货期：3-5天 | - | - | - | - |
|
V37279-25mg |
≥99% | ￥7260.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | LPA1 receptor antagonist 1 是具有高度选择性的，溶血磷脂酸 (LPA1) 受体的一个拮抗剂，其 IC50 值为 25 nM | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 25 nM (LPA1). | ||||||||||||||||||||
| 体内研究： | Oral dosing of LPA1 receptor antagonist 1 in mice causes a dose-dependent reduction in serum histamine levels induced following intravenous LPA stimulation. When mice are orally dosed with LPA1 antagonist 1 (100 mg/kg, aqueous suspension) prior to intravenous LPA injection, the LPA-induced histamine level is significantly blocked A clear PK/PD relationship is demonstrated by the correlation between the levels of LPA1 receptor antagonist 1 and LPA-induced histamine concentrations in plasma. Although AM095 almost completely blocks histamine release (100 mg/kg), analysis of plasma samples revealed more than 65-fold higher concentrations of AM095 than LPA1 receptor antagonist 1 (100 mg/kg). The ability of LPA1 receptor antagonist 1 to block histamine release at much lower plasma concentration suggests that further improvement of pharmacokinetic properties of this chemical class could lower the effective dose. | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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