| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V38023-1mg |
≥99% | ￥820.00 |
货期：3-5天 | - | - | - | - |
|
V38023-5mg |
≥99% | ￥1850.00 |
货期：3-5天 | - | - | - | - |
|
V38023-10mg |
≥99% | ￥2650.00 |
货期：3-5天 | - | - | - | - |
|
V38023-25mg |
≥99% | ￥3210.00 |
货期：3-5天 | - | - | - | - |
|
V38023-50mg |
≥99% | ￥4390.00 |
货期：3-5天 | - | - | - | - |
|
V38023-100mg |
≥99% | ￥5930.00 |
货期：3-5天 | - | - | - | - |
|
| 靶点： | IC50: 9.8 nM (squalene epoxidase, in HepG2 cell homogenates) | ||||||||||||||||||||
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| 体内研究： | Serum lipid levels in hamsters after daily administration of FR194738 and Pravastatin for 10 d are measured. FR194738 reduces the serum levels of total, non high density lipoprotein (HDL) and HDL cholesterol, and triglyceride. Treatment of hamsters with FR194738 increases HMG-CoA reductase activity by 1.3-fold at 32 mg/kg compared to the control group and does not significantly change that at 100 mg/kg. | ||||||||||||||||||||
| 参考文献： | 1. Sawada M, et al. Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells. Eur J Pharmacol. 2001 Nov 9;431(1):11-6. 2. Sawada M, et al. Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7. 3. Sawada M, et al. Inhibition of cholesterol synthesis causes both hypercholesterolemia and hypocholesterolemia in hamsters. Biol Pharm Bull. 2002 Dec;25(12):1577-82. |
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| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京