| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V38620-1mg |
≥99% | ￥1480.00 |
货期：3-5天 | - | - | - | - |
|
V38620-5mg |
≥99% | ￥3790.00 |
货期：3-5天 | - | - | - | - |
|
V38620-10mg |
≥99% | ￥5390.00 |
货期：3-5天 | - | - | - | - |
|
V38620-25mg |
≥99% | ￥8130.00 |
货期：3-5天 | - | - | - | - |
|
V38620-50mg |
≥99% | ￥10900.00 |
货期：3-5天 | - | - | - | - |
|
V38620-100mg |
≥99% | ￥14700.00 |
货期：3-5天 | - | - | - | - |
|
| 体内研究： | Befiradol (F13640; NLX-112) reduces the activity of dorsal raphe serotonergic neurons at 0.2-18.2 μg/kg, i.v. (cumulative doses; ED50=0.69 μg/kg, i.v.) and increases the discharge rate of 80% of mPFC pyramidal neurons in the same dose range (ED50=0.62 μg/kg, i.v.). Both effects are reversed by the subsequent administration of the 5-HT1A receptor antagonist (±)WAY100635. In microdialysis studies, Befiradol (F13640; NLX-112) (0.04-0.63 mg/kg, i.p.) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC. Likewise, Befiradol (F13640; NLX-112) (0.01-2.5 mg/kg, i.p.) dose-dependently increases extracellular DA in mPFC, an effect dependent on the activation of postsynaptic 5-HT1A receptors in mPFC. Local perfusion of Befiradol in mPFC (1-1,000 μM) also increases extracellular DA in a concentration-dependent manner. Both the systemic and local effects of Befiradol are prevented by prior (±)WAY100635 administration. | ||||||||||||||||||||
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| 参考文献： | 1. Lladó-Pelfort L, et al. In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist, F13640, at pre- and postsynaptic 5-HT1A receptors in the rat. Psychopharmacology (Berl). 2012 May;221(2):261-72. | ||||||||||||||||||||
| 保存条件： | 2-8°C,RT,干燥 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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