| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V39351-1mg |
≥98% | ￥660.00 |
货期：3-5天 | - | - | - | - |
|
V39351-5mg |
≥98% | ￥1980.00 |
货期：3-5天 | - | - | - | - |
|
V39351-10mg |
≥98% | ￥3210.00 |
货期：3-5天 | - | - | - | - |
|
V39351-25mg |
≥98% | ￥5190.00 |
货期：3-5天 | - | - | - | - |
|
V39351-50mg |
≥98% | ￥7120.00 |
货期：3-5天 | - | - | - | - |
|
V39351-100mg |
≥98% | ￥9590.00 |
货期：3-5天 | - | - | - | - |
|
V39351-200mg |
≥98% | ￥12900.00 |
货期：3-5天 | - | - | - | - |
|
| 靶点： | IC50: 8 nM (TRPV1 receptor). | ||||||||||||||||||||
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| 体内研究： | Instillation of 50 μL capsaicin solution (10 μg/mL) into the left eye of the rat evokes 12.9±1.3 wiping movements within 3 min. Pretreating the rats with 0.4 or 1 mg/kg i.p. JYL 1421 does not influence significantly the wiping behavior, but 2-5 mg/kg dose-dependently reduces the number of wiping movements. The ID50 value is 4.6 mg/kg. The mean arterial pressure of untreated rats is 109.9±4.2 Hgmm (n=6). One and 2 μg/kg capsaicin i.v. injection evokes a transient drop of blood pressure by 47.4±4.7 and 59.6±4.2 Hgmm (n=6), respectively. Both applied doses of JYL 1421 (0.4 and 1.6 mg/kg) fail to evoke hypotension. JYL 1421 dose-dependently inhibits the capsaicin-induced fall in blood pressure as shown by the need for higher capsaicin doses to elicit the reflex hypotension after JYL 1421 administration than before treatment. Capsazepine fails to induce a significant inhibition of the capsaicin-evoked hypotension up to a dose of 2 mg/kg. | ||||||||||||||||||||
| 参考文献： | 1. Jakab B, et al. Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat. Eur J Pharmacol. 2005 Jul 4;517(1-2):35-44. | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京