| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V39966-1mg |
≥99% | ￥1930.00 |
货期：3-5天 | - | - | - | - |
|
V39966-5mg |
≥99% | ￥4690.00 |
货期：3-5天 | - | - | - | - |
|
V39966-10mg |
≥99% | ￥6570.00 |
货期：3-5天 | - | - | - | - |
|
V39966-25mg |
≥99% | ￥9750.00 |
货期：3-5天 | - | - | - | - |
|
V39966-50mg |
≥99% | ￥12900.00 |
货期：3-5天 | - | - | - | - |
|
V39966-100mg |
≥99% | ￥17500.00 |
货期：3-5天 | - | - | - | - |
|
| 靶点： | IC50: 120 nM (PTP1B), 120 nM (TCPTP) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体内研究： | In diet-induced obese (DIO) mice, PTP1B-IN-3 (compounds 3g) exhibits dose dependent inhibition (60%, 80% and 100% inhibition at 1, 3 and 10 mg/kg, respectively) of glucose excursion when given orally 2 h before oral glucose challenge with an estimated ED50 of 0.8 mg/kg. In the NDL2 Ptpn1 transgenic mice, PTP1B-IN-3 (compounds 3g; orally; 30 mg/kg for 21 days) shows a significant delay in the onset of tumor development in NDL2 Ptpn1+/+ mice, extending the median tumor free days (T50) from 28 days to 75 days. In diet-induced obese (DIO) mice, PTP1B-IN-3 (compounds 3g) exhibits good oral bioavailability (F of 24%), slow clearance (CL of 0.71 mL/kg/min), and good elimination half live (t1/2 of 6 h). The oral bioavailability in higher species such as rats (F of 4%) and squirrel monkeys (F of 2%) are substantially lower but excellent exposures are achieved with oral dosing. |
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| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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