| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V41057-5mg |
98% | ￥1190.00 |
货期：3-5天 | - | - | - | - |
|
V41057-10mg |
98% | ￥1910.00 |
货期：3-5天 | - | - | - | - |
|
V41057-25mg |
98% | ￥3830.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor, with an IC50 of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC50 of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy. |
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| 靶点： | PI4K:0.9 ± 0.1 nM (IC50);PI3Kδ:104 ± 3 nM (IC50);PI3Kα:191 ± 36 nM (IC50);PI3Kγ:324 ± 19 nM (IC50);PI3Kβ:392 ± 27 nM (IC50);Vps34:681 ± 25 nM (IC50) | ||||||||||||||||||||
| 体外研究： | CHMFL-PI4K-127 (compound 15g) displays high selectivity against PfPI4K over human lipid and protein kinase. CHMFL-PI4K-127 exhibits EC50 values of 23–47 nM against a panel of the drug-resistant strains of P. falciparum. |
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| 体内研究： | CHMFL-PI4K-127 (compound 15g) (Orally; 0-80 mg/kg/day for 7 days; 0-15 mg/kg, once) exhibits the antimalaria efficacy in both blood stage (80 mg/kg) and liver stage (1 mg/kg) of Plasmodium in infected rodent model. | ||||||||||||||||||||
| 参考文献： | 1. 6'-chloro-N-methyl-5'-(phenylsulfonamido)-[3,3'-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium. Eur J Med Chem. 2020 Feb 15;1 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8°C,Inert atmosphere | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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