| 产品描述: | Rabies Virus Glycoprotein 是由 29 个氨基酸残基构成的细胞穿透肽,来源于狂犬病病毒糖蛋白,它能够穿过血脑屏障,进入脑细胞。 |
| 体外研究: |
RVG peptide is successfully used to carry a variety of cargos into brain cells such as plasmids, siRNAs, proteins, and nanoparticles. RVG29 can govern the interaction of viral particles with at least three known receptors, including neural cell adhesion molecule (NCAM), the p75 neurotrophin receptor (P75NTR), and nicotinic acetylcholine receptors (NAChRs). The RVG29 peptide enhances the brain-specific function of a range of systemically delivered agents, particularly nucleic acids. |
| 参考文献: |
1. Zou Z, et al. Cre Fused with RVG Peptide Mediates Targeted Genome Editing in Mouse Brain Cells In Vivo. Int J Mol Sci. 2016 Dec 14;17(12). pii: E2104.
2. Cook RL, et al. A critical evaluation of drug delivery from ligand modified nanoparticles: Confounding small molecule distribution and efficacy in the central nervous system. J Control Release. 2015 Dec 28;220(Pt A):89-97. |
| 保存条件: |
-80°C,干燥 |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
0.306 ml |
1.531 ml |
3.061 ml |
| 5 mM |
0.061 ml |
0.306 ml |
0.612 ml |
| 10 mM |
0.031 ml |
0.153 ml |
0.306 ml |
| 50 mM |
0.006 ml |
0.031 ml |
0.061 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |