货号	规格	价格	上海	北京	珠海	重庆	武汉
V41132-1mg	99%	￥300.00 V41132-1mg ￥300.00 3-5天	0 货期：3-5天	-	-	-	-
V41132-5mg	99%	￥600.00 V41132-5mg ￥600.00 3-5天	0 货期：3-5天	-	-	-	-
V41132-10mg	99%	￥1000.00 V41132-10mg ￥1000.00 3-5天	0 货期：3-5天	-	-	-	-
V41132-25mg	99%	￥2000.00 V41132-25mg ￥2000.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

HLF1-11，一种人乳铁蛋白衍生肽，是一种广谱抗菌剂。HLF1-11 抑制 MPO (human) 的活性。HLF1-11 还使 GM-CSF 驱动的单核细胞向巨噬细胞分化，并增强其免疫反应。

体外研究：

hLF1-11 (1, 10, and 100 μg/mL) directs differentiation of monocytes toward a macrophage subset during granulocyte-macrophage colony-stimulating factor (GM-CSF)-driven monocytes differentiation.

hLF1-11 (0.5-250 μg/mL) inhibits human MPO activity.

hLF1-11 (100 μg/mL, 90 min) inhibits ROS induction induced by LPS in monocytes.

hLF1-11 (8-34 μΜ, 2 h) is active against fluconazole-resistant C. albicans.

体内研究：

hLF1-11 (20 mg/kg, injected into the debrided tibial cavity) shows ability against MRSA osteomyelitis in rabbits.

hLF1-11 (40 μg/kg, i.v.) is active against C. albicans-infected mice.

参考文献：

1. Marty Wulferink, et al. The Peptide hLF1-11 as Broad Spectrum Antmicrobial Prophylaxis in HSCT Patients. Blood (2005) 106 (11): 3241.

2. van der Does AM, et al. Antimicrobial peptide hLF1-11 directs granulocyte-macrophage colony-stimulating factor-driven monocyte differentiation toward macrophages with enhanced recognition and clearance of pathogens. Antimicrob Agents Chemother. 2010 Feb;54(2):811-6.

3. van der Does AM, et al. The human lactoferrin-derived peptide hLF1-11 exerts immunomodulatory effects by specific inhibition of myeloperoxidase activity. J Immunol. 2012 May 15;188(10):5012-9.

4. Faber C, et al. Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model. Antimicrob Agents Chemother. 2005 Jun;49(6):2438-44.

5. Lupetti A, et al. Candidacidal activities of human lactoferrin peptides derived from the N terminus. Antimicrob Agents Chemother. 2000 Dec;44(12):3257-63.

6. upetti A, et al. Human lactoferrin-derived peptide's antifungal activities against disseminated Candida albicans infection. J Infect Dis. 2007 Nov 1;196(9):1416-24.

保存条件：

-80°C,干燥,避光,充氮

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.727 ml	3.637 ml	7.275 ml
5 mM	0.145 ml	0.727 ml	1.455 ml
10 mM	0.073 ml	0.364 ml	0.727 ml
50 mM	0.015 ml	0.073 ml	0.145 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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