货号	规格	价格	上海	北京	珠海	重庆	武汉
V43415-5mg	98%	￥846.00 V43415-5mg ￥846.00 现货	40 >10	-	-	-	-
V43415-10mg	98%	￥1190.00 V43415-10mg ￥1190.00 现货	20 >10	-	-	-	-
V43415-25mg	98%	￥2030.00 V43415-25mg ￥2030.00 现货	8 8	-	-	-	-
V43415-50mg	98%	￥3480.00 V43415-50mg ￥3480.00 现货	4 4	-	-	-	-
V43415-100mg	98%	￥5570.00 V43415-100mg ￥5570.00 现货	2 2	-	-	-	-

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产品描述：

RS47 (Compound 1a) is a selective inhibitor of the non-canonical NF-κB signaling pathway targeting RelB with a Kd of 1.1 μM. RS47 competitively blocks RelB binding to target DNA, inhibiting downstream gene (e.g., BCL3, PIM2) expression, thereby suppressing tumor cell proliferation. RS47 is promising for research of cancers with aberrant activation of the non-canonical NF-κB pathway, such as colorectal cancer and B lymphoma.

参考文献：

1. Li C, et al. Development of RelB-targeting small-molecule inhibitors of non-canonical NF-κB signaling with antitumor efficacy. Mol Ther. 2025 Apr 2;33(4):1519-1534.
2. Bassetto M, et al. Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. Eur J Med Chem. 2016 Nov 10;123:31-47.

溶解性：

可溶于DMSO

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.821 ml	14.107 ml	28.214 ml
5 mM	0.564 ml	2.821 ml	5.643 ml
10 mM	0.282 ml	1.411 ml	2.821 ml
50 mM	0.056 ml	0.282 ml	0.564 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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RS47

2-(1-(2-(5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)hydrazineylidene)ethyl)benzene-1,4-diol

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)