货号	规格	价格	上海	北京	珠海	重庆	武汉
V43579-5mg	≥98%	￥2190.00 V43579-5mg ￥2190.00 3-5天	0 货期：3-5天	-	-	-	-
V43579-10mg	≥98%	￥3590.00 V43579-10mg ￥3590.00 3-5天	0 货期：3-5天	-	-	-	-
V43579-25mg	≥98%	￥6470.00 V43579-25mg ￥6470.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

LKY-047, a Decursin derivative, is a potent and selective reversible competitive cytochrome P45022J2 (CYP2J2) inhibitor with an IC50 of 1.7 μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A.

靶点：

CYP2J2:1.7 μM (IC50)

体内研究：

LKY-047 is a strong competitive inhibitor of CYP2J2-mediated astemizole O-demethylase and terfenadine hydroxylase activity, with Ki values of 0.96 μM and 2.61 μM, respectively. LKY-047 also acted as an uncompetitive inhibitor of CYP2J2-mediated ebastine hydroxylation with a Ki value of 3.61 μM.
At 20 μM LKY-047 concentration, approximately 20-fold greater than the Ki value, LKY-047 is found to inhibit CYP2J2 by 85.3%, and only slightly affecting the enzyme activities of the other P450s tested. LKY-047 weakly inhibits CYP2D6 enzyme activity (37.2%) at 20 μM concentration.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.373 ml	11.865 ml	23.73 ml
5 mM	0.475 ml	2.373 ml	4.746 ml
10 mM	0.237 ml	1.187 ml	2.373 ml
50 mM	0.047 ml	0.237 ml	0.475 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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