货号	规格	价格	上海	北京	珠海	重庆	武汉
V43764-1mg	≥98%	￥1000.00 V43764-1mg ￥1000.00 3-5天	0 货期：3-5天	-	-	-	-
V43764-5mg	≥98%	￥2500.00 V43764-5mg ￥2500.00 3-5天	0 货期：3-5天	-	-	-	-
V43764-10mg	≥98%	￥3680.00 V43764-10mg ￥3680.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

体外研究：

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.

保存条件：

-20°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.635 ml	3.175 ml	6.35 ml
5 mM	0.127 ml	0.635 ml	1.27 ml
10 mM	0.063 ml	0.317 ml	0.635 ml
50 mM	0.013 ml	0.063 ml	0.127 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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