货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V43815-1mg	≥98%	￥7190.00 V43815-1mg ￥7190.00 3-5天	0 货期：3-5天	-	-	-	-
V43815-5mg	≥98%	￥19200.00 V43815-5mg ￥19200.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Nintedanib-d8 is deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

体外研究：

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

参考文献：

1. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
2. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782.
3. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.826 ml	9.13 ml	18.259 ml
5 mM	0.365 ml	1.826 ml	3.652 ml
10 mM	0.183 ml	0.913 ml	1.826 ml
50 mM	0.037 ml	0.183 ml	0.365 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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