货号	规格	价格	上海	北京	珠海	重庆	武汉
V43820-5mg	≥98%	￥790.00 V43820-5mg ￥790.00 3-5天	0 货期：3-5天	-	-	-	-
V43820-10mg	≥98%	￥1270.00 V43820-10mg ￥1270.00 3-5天	0 货期：3-5天	-	-	-	-
V43820-25mg	≥98%	￥2520.00 V43820-25mg ￥2520.00 3-5天	0 货期：3-5天	-	-	-	-
V43820-50mg	≥98%	￥4000.00 V43820-50mg ￥4000.00 3-5天	0 货期：3-5天	-	-	-	-
V43820-100mg	≥98%	￥6400.00 V43820-100mg ￥6400.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

HEPES-d18 is the deuterium labeled HEPES. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis.

体外研究：

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

参考文献：

1. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
2. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828.
3. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 201066(Pt 4):482-492.
4. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 201814(3):437-449.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.9 ml	19.499 ml	38.999 ml
5 mM	0.78 ml	3.9 ml	7.8 ml
10 mM	0.39 ml	1.95 ml	3.9 ml
50 mM	0.078 ml	0.39 ml	0.78 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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