货号	规格	价格	上海	北京	珠海	重庆	武汉
V43829-5mg	≥98%	￥900.00 V43829-5mg ￥900.00 3-5天	0 货期：3-5天	-	-	-	-
V43829-10mg	≥98%	￥1500.00 V43829-10mg ￥1500.00 3-5天	0 货期：3-5天	-	-	-	-
V43829-25mg	≥98%	￥3100.00 V43829-25mg ￥3100.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.

体外研究：

In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acetate acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide acetate activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels.
Phe-Met-Arg-Phe, amide (1 μM) acetate significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas.
Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) acetate is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM).

体内研究：

Phe-Met-Arg-Phe, amide (FMRFamide) acetate stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic contr웿Ůñ샮㡽䇘睜⪰ޏࠃ䇩睜䇩睜ȂӤ晐睦Ӥ晐睦Ӥ峀睜弴睜ڤ犐ƈڤ郥댻嬧睜Ӥ乨Ƥ鄩댻婯睜Љ�ޝ乜Ƥ媜睜ӤItemҮ쎾番莰ଁ뢜సങ獲䥷唍⃄హ⻌హ�唒⸼హଁ敖ﰨ唎

参考文献：

1. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28.
2. Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin웿Ůñ샮㡽䇘睜⪰ޏࠃ䇩睜䇩睜ȂӤ晐睦Ӥ晐睦Ӥ峀睜弴睜ڤ犐ƈڤ郥댻嬧睜Ӥ乨Ƥ鄩댻婯睜Љ�ޝ乜Ƥ媜睜ӤItemҮ쎾番莰ଁ뢜సങ獲䥷唍⋠హ⾈హ�唒⻸హଁ敖ﰨ唎њﰰ䨬{�唒⻸హ

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.518 ml	7.589 ml	15.179 ml
5 mM	0.304 ml	1.518 ml	3.036 ml
10 mM	0.152 ml	0.759 ml	1.518 ml
50 mM	0.03 ml	0.152 ml	0.304 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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