货号	规格	价格	上海	北京	珠海	重庆	武汉
V43923-1mg	≥98%	￥790.00 V43923-1mg ￥790.00 3-5天	0 货期：3-5天	-	-	-	-
V43923-5mg	≥98%	￥2890.00 V43923-5mg ￥2890.00 3-5天	0 货期：3-5天	-	-	-	-
V43923-10mg	≥98%	￥5200.00 V43923-10mg ￥5200.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3.

体外研究：

2-Chlorohexadecanoic acid (2-ClHA; 10 μM; 4, 6 h) results phosphorylation of eIF2α starting 4 h post treatment, while total eIF2α levels remained unchanged incubation of hCMEC/D3 cells. 2-Chlorohexadecanoic acid increases expression of ATF4, a target gene of eIF2α.
2-Chlorohexadecanoic acid (25 μM, 30 min) induces a decrease in the FRET ratio signal of ERAT by 40%, indicating significantly diminished [ATP]ER in cells that were treated with 2-Chlorohexadecanoic acid.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.438 ml	17.19 ml	34.38 ml
5 mM	0.688 ml	3.438 ml	6.876 ml
10 mM	0.344 ml	1.719 ml	3.438 ml
50 mM	0.069 ml	0.344 ml	0.688 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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