货号	规格	价格	上海	北京	珠海	重庆	武汉
V43988-1mg	≥98%	￥670.00 V43988-1mg ￥670.00 3-5天	0 货期：3-5天	-	-	-	-
V43988-5mg	≥98%	￥1429.00 V43988-5mg ￥1429.00 3-5天	0 货期：3-5天	-	-	-	-
V43988-10mg	≥98%	￥2428.00 V43988-10mg ￥2428.00 3-5天	0 货期：3-5天	-	-	-	-
V43988-25mg	≥98%	￥5159.00 V43988-25mg ￥5159.00 3-5天	0 货期：3-5天	-	-	-	-
V43988-50mg	≥98%	￥8770.00 V43988-50mg ￥8770.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer-related research, such as hepatocellular carcinoma (HCC) and oesophageal carcinoma.

靶点：

STAT3

体内研究：

STAT3-IN-12 (compound 24, 0-10 μM approximately, 72 h) inhibits cancer cell growth and migration in HepG2 and EC109 cells.
STAT3-IN-12 (0-20 μM, 16 h) binds to the STAT3 protein and inhibits IL-6-mediated STAT3 phosphorylation, also inhibts STAT3 nuclear localization and dimerization in EC109 and HepG2 cells.
STAT3-IN-12 (0-20 μM, 48 h) induces cell apoptosis as well as cycle arrest in HepG2 and EC109 cells.

参考文献：

1. Yi-Chen Liu, et al. Benzobis(imidazole) derivatives as STAT3 signal inhibitors with antitumor activity.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.2 ml	11 ml	21.999 ml
5 mM	0.44 ml	2.2 ml	4.4 ml
10 mM	0.22 ml	1.1 ml	2.2 ml
50 mM	0.044 ml	0.22 ml	0.44 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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