货号	规格	价格	上海	北京	珠海	重庆	武汉
V44070-1mg	≥98%	￥1240.00 V44070-1mg ￥1240.00 3-5天	0 货期：3-5天	-	-	-	-
V44070-5mg	≥98%	￥3110.00 V44070-5mg ￥3110.00 3-5天	0 货期：3-5天	-	-	-	-
V44070-10mg	≥98%	￥4980.00 V44070-10mg ￥4980.00 3-5天	0 货期：3-5天	-	-	-	-
V44070-25mg	≥98%	￥8980.00 V44070-25mg ￥8980.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Menin-MLL inhibitor-22 (compound C20) is an orally active inhibitor of the interaction between menin and mixed lineage leukemia (MLL) (IC50=7 nM). Menin-MLL inhibitor-22 binds menin protein and inhibits cancer cell growth (MV4 cells, IC50=0.3 μM). Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome).

体外研究：

Menin-MLL inhibitor-22 (1 μM; 60 min) possesses good stability and low clearance rate in liver microsomes.
Menin-MLL inhibitor-22 (1 and 10 μM; 24 h) inhibits MLL-r Leukemia cells MV4;11 growth and (0.1-10 μM; 24 h) decreases the expression of the HOXA9 and MEIS1 induced by menin-MLL interaction.
Menin-MLL inhibitor-22 (1, and 10 μM; 7 d) increases the amount of CD11b, a differentiation marker of myeloid cells, indicating a reverse the differentiation arrest of MLL-r leukemia cells.
Menin-MLL inhibitor-22 (1, and 10 μM; 24 h) induces cell apoptosis and G0/G1 cell cycle arrest.

体内研究：

Menin-MLL inhibitor-22 (6 mg/kg and 30 mg/kg; p.o.; every second day for 16 days) shows potent antitumor activity in the MV4;11 subcutaneous xenograft models of MLL-rearranged leukemia.

Pharmacokinetic Properties in SD Rats

参考文献：

1. Lei H, et al. Discovery of Novel, Potent, and Selective Small-Molecule Menin-Mixed Lineage Leukemia Interaction Inhibitors through Attempting Introduction of Hydrophilic Groups. J Med Chem. 2022 Oct 13;65(19):13413-13435.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.768 ml	8.838 ml	17.676 ml
5 mM	0.354 ml	1.768 ml	3.535 ml
10 mM	0.177 ml	0.884 ml	1.768 ml
50 mM	0.035 ml	0.177 ml	0.354 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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