货号	规格	价格	上海	北京	珠海	重庆	武汉
V44110-5mg	≥98%	￥1790.00 V44110-5mg ￥1790.00 3-5天	0 货期：3-5天	-	-	-	-
V44110-10mg	≥98%	￥2990.00 V44110-10mg ￥2990.00 3-5天	0 货期：3-5天	-	-	-	-
V44110-25mg	≥98%	￥5990.00 V44110-25mg ￥5990.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has potent pan anti-cancer activity against a broad range of cancer phenotypes.

体外研究：

TRX-E-002-1 shows broad cytotoxic activity against ovarian, prostate and lung cancer cells, with IC50 values of ≤0.1 μM (SK-OV-3, JAM, OVCAR-3 cells: IC50=0.023-0.065 μM; DU145, PC3; C4-2B cells: IC50=0.014-0.096 μM; A549 cells: IC50=0.058 μM). Activity in pancreatic and colorectal cancer cells and glioblastoma cells are more variable.
Cantrixil (0.2 μM; 2-24 hours) shows high levels of phosphorylated c-Jun (p-c-Jun) and low levels of phosphorylated-ERK (p-ERK).
Cantrixil (2.45 μM; 2-24 hours) induces a significant increase in both caspase-3/7 and caspase-9 activity at 16 and 24 hours.
TRX-E-002-1 inhibits multiple cytochrome P450 drug-metabolizing enzymes, including CYP2C9, CYP2C8, CYP2C19, CYP2B6, CYP3A4, CYP2D6, CYP2A6 and CYP1A2. IC50 values ranges from 1.5 to 75 μM (612-30,600 ng/mL).

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.448 ml	12.241 ml	24.483 ml
5 mM	0.49 ml	2.448 ml	4.897 ml
10 mM	0.245 ml	1.224 ml	2.448 ml
50 mM	0.049 ml	0.245 ml	0.49 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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