货号	规格	价格	上海	北京	珠海	重庆	武汉
V44225-1mg	≥98%	￥1440.00 V44225-1mg ￥1440.00 3-5天	0 货期：3-5天	-	-	-	-
V44225-5mg	≥98%	￥3640.00 V44225-5mg ￥3640.00 3-5天	0 货期：3-5天	-	-	-	-
V44225-10mg	≥98%	￥5840.00 V44225-10mg ￥5840.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.

体外研究：

Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv[1].

体内研究：

AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.82 ml	9.099 ml	18.197 ml
5 mM	0.364 ml	1.82 ml	3.639 ml
10 mM	0.182 ml	0.91 ml	1.82 ml
50 mM	0.036 ml	0.182 ml	0.364 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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