货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V44245-1mg	≥98%	￥3790.00 V44245-1mg ￥3790.00 3-5天	0 货期：3-5天	-	-	-	-
V44245-5mg	≥98%	￥9280.00 V44245-5mg ￥9280.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

MD-222 is the first-in-class highly potent PROTAC degrader of MDM2. MD-222 consists of ligands for Cereblon and MDM2. MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects.

体外研究：

MD-222 (1-30 nM; 1-2 hours) treatment shows very effective in reducing the levels of MDM2 protein and increasing the levels of p53 in a time- and dose-dependent manner in RS4;11 and RS4;11/IRMI-2 cells.
MD-222 (30-100 nM; 6 hours) is effective in increasing the expression of several p53-targeted genes, such as MDM2, CDKN1A, and PUMA in RS4;11 cells, indicating strong activation of p53.
MD-222 (4 days) shows cell growth inhibitory activity in RS4;11 cells with an IC50 of 5.5 nM, and has no effect on RS4;11/IRMI-2, MDA-MB-231 and MDA-MB-468 cells.

保存条件：

-20°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.119 ml	5.594 ml	11.188 ml
5 mM	0.224 ml	1.119 ml	2.238 ml
10 mM	0.112 ml	0.559 ml	1.119 ml
50 mM	0.022 ml	0.112 ml	0.224 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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