货号	规格	价格	上海	北京	珠海	重庆	武汉
V44274-5mg	≥98%	￥650.00 V44274-5mg ￥650.00 现货	3 3	-	-	-	-
V44274-10mg	≥98%	￥1000.00 V44274-10mg ￥1000.00 现货	2 2	-	-	-	-
V44274-50mg	≥98%	￥4000.00 V44274-50mg ￥4000.00 现货	2 2	-	-	-	-

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产品描述：

Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

体外研究：

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	6.277 ml	31.387 ml	62.775 ml
5 mM	1.255 ml	6.277 ml	12.555 ml
10 mM	0.628 ml	3.139 ml	6.277 ml
50 mM	0.126 ml	0.628 ml	1.255 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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