货号	规格	价格	上海	北京	珠海	重庆	武汉
V44307-1mg	≥98%	￥900.00 V44307-1mg ￥900.00 3-5天	0 货期：3-5天	-	-	-	-
V44307-5mg	≥98%	￥2200.00 V44307-5mg ￥2200.00 3-5天	0 货期：3-5天	-	-	-	-
V44307-10mg	≥98%	￥3300.00 V44307-10mg ￥3300.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

HIV-1 TAT (48-60) is a cell-penetrating peptide derived from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way.

体外研究：

Studies show that exogenous Tat protein is able to translocate through the plasma membrane and to reach the nucleus to transactivate the viral genome. The HIV-1 TAT (48-60) peptide, which contains the basic domain of the full length peptide only, retains the full translocation activity and even appears more efficient in terms of nuclear localization when compared with the other active peptides at the standard dose of 1 mM. Cell-penetrating peptides are regarded as promising vectors for intracellular delivery of large, hydrophilic molecules. An apparently endocytotic uptake of HIV-1 TAT (48-60) is observed by confocal laser scanning microscopy. HIV-1 TAT (48-60) induces the formation of rodlike, presumably inverted micelles in DMPC, which may represent intermediates during the translocation across eukaryotic membranes.

参考文献：

1. Vivès E, et al. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem. 1997 Jun 20;272(25):16010-7.

保存条件：

-80°C, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.582 ml	2.909 ml	5.817 ml
5 mM	0.116 ml	0.582 ml	1.163 ml
10 mM	0.058 ml	0.291 ml	0.582 ml
50 mM	0.012 ml	0.058 ml	0.116 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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