| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
V44441-5mg |
≥98% | ￥1840.00 |
货期：3-5天 | - | - | - | - |
|
V44441-10mg |
≥98% | ￥2940.00 |
货期：3-5天 | - | - | - | - |
|
V44441-25mg |
≥98% | ￥5890.00 |
货期：3-5天 | - | - | - | - |
|
V44441-50mg |
≥98% | ￥7770.00 |
货期：3-5天 | - | - | - | - |
|
V44441-100mg |
≥98% | ￥12400.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers. | ||||||||||||||||||||
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| 体外研究： | IMPDH-IN-4 (Compound 9) 对 NAD 合成无显著抑制作用 (IC50 = 48 μM)，也不抑制 S462 细胞中的 NAMPT 活性和 NMN 水平。 IMPDH-IN-4 对 S462 细胞 (IC50 = 1.20 μM) 和表达 Cas9 的 HCT116 细胞 (IC50 = 20.8 nM) 有毒性。 IMPDH-IN-4 (30 天) 依赖于 NAMPT 和 NMNAT1 来实现敲除 HCT116 和 S462 细胞中的 NMNAT1 的活性。 |
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| 参考文献： | 1. Theodoropoulos PC, et al. Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers. ACS Chem Biol. 2024 Jun 21;19(6):1339-1350. |
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| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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