货号	规格	价格	上海	北京	珠海	重庆	武汉
V44467-1mg	≥98%	￥2030.00 V44467-1mg ￥2030.00 3-5天	0 货期：3-5天	-	-	-	-
V44467-5mg	≥98%	￥5090.00 V44467-5mg ￥5090.00 3-5天	0 货期：3-5天	-	-	-	-
V44467-10mg	≥98%	￥8140.00 V44467-10mg ￥8140.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research.

体外研究：

SSR411298 (0.3, 1, 3 mg/kg; p.o.; twice a day during 2 days; 60 minutes before pretest, immediately after, and 60 minutes before the second session of testing) produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress model, restoring notably the development of inadequate coping responses to chronic stress in male Wistar rats weighing 235-290 g[1].
SSR411298 (0.3, 1, 3, 10 mg/kg; po; single dose; two hours prior to sacrifice) produces a significant global increase of tissular AEA, PEA and OEA levels in the hippocampus, but not of 2-AG levels[1].

体内研究：

SSR411298 (0.1, 1, 10, 100, 1000, 10000 nM) inhibits mouse brain FAAH in a concentration-dependent manner.
SSR411298 produces maximal inhibition of FAAH between 0.3 and 30 mg/kg in the ex-vivo experiment.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.485 ml	12.424 ml	24.848 ml
5 mM	0.497 ml	2.485 ml	4.97 ml
10 mM	0.248 ml	1.242 ml	2.485 ml
50 mM	0.05 ml	0.248 ml	0.497 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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